The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out
with the help of recent advances in genetic technology. Linkage studies and association …

In complex diseases like ALS, there are multiple genetic and environmental factors all
contributing to disease liability. The genetic factors causing susceptibility to developing ALS …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
characterised by a rapid loss of lower and upper motor neurons. As a complex disease, the …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results
in progressive degeneration of motor neurons, ultimately leading to paralysis and death …

Replication of poliovirus RNA is accomplished by the error-prone viral RNA-dependent RNA
polymerase and hence is accompanied by numerous mutations. In addition, genetic errors …

Rationale: Vascular endothelial growth factor (VEGF), a major proangiogenic agent, exerts
its proangiogenic action by binding to VEGF receptor 2 (VEGFR2), the activity of which is …

The intricate connection between the gut and the brain involves multiple routes. Several viral
families begin their infection cycle in the intestinal tract. However, amongst the long list of …

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease whose etiology
remains poorly understood. Since the genetic basis of disease is known in only a small …

Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central
nervous system (CNS) resulting in flaccid paralysis. The development of new animal and …

The Sabin oral poliovirus vaccine (OPV) readily undergoes changes in antigenic sites upon
replication in humans. Here, a set of antigenically altered descendants of the three OPV …