Most of the vesicular transport pathways inside the cell are facilitated by molecular motors
that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that …

Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with
huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion …

The origin of the unique directionality of myosin has been a problem of fundamental and
practical importance. This work establishes in a conclusive way that the directionality is …

Endocytic recycling is a complex itinerary, critical for many cellular processes. Membrane
tubulation is a hallmark of recycling endosomes (REs), mediated by KIF13A, a kinesin-3 …

The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility,
intracellular trafficking and ciliary function. Determining the cellular function of each kinesin …

Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of
frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic …

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal progressive
degenerative disorder of motor neurons that overlaps with frontotemporal lobar …

Unlike virtually any other cells in the human body, neurons are tasked with the unique
problem of transporting important factors from sites of synthesis at the cell bodies, across …

Background Kinesin-3 family motors drive diverse cellular processes and have significant
clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors …

A complex cellular environment poses challenges for single-molecule motility analysis.
However, advancement in imaging techniques have improved single-molecule studies and …