Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive
degenerative joint disorder, OA is characterized by cartilage damage, changes in the …

Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a
process of wear and tear but rather abnormal remodelling and joint failure of an organ. The …

Once believed to be limited to articular cartilage, osteoarthritis is now considered to be an
organ disease of the “whole joint.” Damage to the articular surface can lead to, be caused …

Lesion positioning therapy optimizes medical treatment by directly targeting lesions.
However, strong physical barriers greatly hinder its wide use. Here, the Chinese …

Bone marrow edema (BME) is a descriptive term which identifies a specific magnetic
resonance imaging (MRI) pattern that can be observed in a number of clinical entities, which …

To listen to the podcast associated with this article, please select one of the following:
iTunes, Google Play, or direct download. OBJECTIVE. The purpose of this article is to …

Abstract Type 2 diabetes (T2D) is associated with systemic abnormal bone remodeling and
bone loss. Meanwhile, abnormal subchondral bone remodeling induces cartilage …

Abstract Background Bone marrow lesions (BMLs) are useful diagnostic and prognostic
markers in knee osteoarthritis (OA), but what they represent at the tissue level remains …

Objective. The aim of this randomized, double-blind, placebo-controlled study was to assess
the efficacy of iv neridronate in controlling pain in patients with acute painful knee OA …

ABSTRACT OBJECTIVE: To evaluate the use of subchondroplasty in the treatment of bone
marrow lesions in an initial series of five cases. METHODS: The study included patients …