The roles of proteolytic cleavage have been intensively investigated and discussed during
the past two decades. This irreversible chemical process has been frequently reported to …

Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …

Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific
amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key …

The importance of 3D protein structure in proteolytic processing is well known. However,
despite the plethora of existing methods for predicting proteolytic sites, only a few of them …

The intramembrane protease γ-secretase activates important signaling molecules, such as
Notch receptors. It is still unclear, however, how different elements within the primary …

Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is
implicated in Alzheimer's disease pathogenesis. Biophysical data have suggested that the N …

Intramembrane proteases play a pivotal role in biology and medicine, but how these
proteases decode cleavability of a substrate transmembrane (TM) domain remains unclear …

Both protease-and reactive oxygen species (ROS)-mediated proteolysis are thought to be
key effectors of tissue remodeling. We have previously shown that comparison of amino acid …

Abstract Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl
protease that causes secretion of extracellular domains from type-II transmembrane …

CleavPredict (http://cleavpredict. sanfordburnham. org) is a Web server for substrate
cleavage prediction for matrix metalloproteinases (MMPs). It is intended as a computational …