Computational crystal structure prediction (CSP) methods can now be applied to the smaller
pharmaceutical molecules currently in drug development. We review the recent uses of …

Crystallization abounds in nature and industrial practice. A plethora of indispensable
products ranging from agrochemicals and pharmaceuticals to battery materials are …

This review considers advances in the understanding of active pharmaceutical ingredient
polymorphism since around 2010 mainly from a structural view point, with a focus on twelve …

The nonphotochemical laser-induced nucleation (NPLIN) phenomenon of an inorganic
compound, ethylenediamine sulfate, exhibiting crystal chirality has been investigated …

Highlights•Crystal structure prediction studies have been carried out with the pharmaceutical
industry.•Crystal energy landscapes can help to define solid form landscapes.•Crystal …

Cocrystallization is a technique to optimize solid forms that shows great potential to improve
the solubility of active pharmaceutical ingredients (APIs). In some systems, an API can form …

Non-photochemical laser-induced nucleation (NPLIN) is the formation of a new phase from
a metastable phase by the action of light on matter. Using millijoule, nanosecond laser …

There has been significant recent interest in differentiating multicomponent solid forms, such
as salts and cocrystals, and, where appropriate, in determining the position of the proton in …

Recently, laser-induced nucleation (LIN) has been attracting significant attention because of
its many advantages, including non-mechanical contact, spatiotemporal controllability, and …

The nucleation of glycine from aqueous supersaturated solution has been studied using non-
photochemical laser-induced nucleation (NPLIN), ultrasound (sonocrystallization), and …