Centrioles are microtubule-based cell organelles present in most eukaryotes. They
participate in the control of cell division as part of the centrosome, the major microtubule …

Mutations in human CEP290 cause cilia-related disorders that range in severity from
isolated blindness to perinatal lethality. Here, we describe a Chlamydomonas reinhardtii …

Cilia and flagella are surface-exposed, finger-like organelles whose core consists of a
microtubule (MT)-based axoneme that grows from a modified centriole, the basal body. Cilia …

Generation and subsequent analysis of mutants is critical to understanding the functions of
genes and proteins. Here we describe TIM, an efficient, cost-effective, CRISPR-based …

Centrioles form the core of the centrosome in animal cells and function as basal bodies that
nucleate and anchor cilia at the plasma membrane. In this paper, we report that Cep120 …

I thoroughly discuss ciliary transition zone (TZ) evolution, highlighting many overlooked
evolutionarily significant ultrastructural details. I establish fundamental principles of TZ …

The eyespot of the unicellular green alga Chlamydomonas reinhardtii is a photoreceptive
organelle required for phototaxis. Relative to the anterior flagella, the eyespot is …

During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the
formation of cilia/flagella and template the nine doublet microtubules of the flagellar …

The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim
or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and …

Correct centriole/basal body positioning is required for numerous biological processes, yet
how the cell establishes this positioning is poorly understood. Analysis of centriolar/basal …