Pathogenic mechanisms of HIV disease
Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
Targeting early infection to prevent HIV-1 mucosal transmission
AT Haase - Nature, 2010 - nature.com
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …
Chemokines and their receptors: drug targets in immunity and inflammation
A Viola, AD Luster - Annu. Rev. Pharmacol. Toxicol., 2008 - annualreviews.org
The chemokine system coordinates leukocyte migration in immunity and inflammation and is
implicated in the pathogenesis of many human diseases. Although several successful …
implicated in the pathogenesis of many human diseases. Although several successful …
Focus on antivirally active sulfated polysaccharides: from structure–activity analysis to clinical evaluation
T Ghosh, K Chattopadhyay, M Marschall… - …, 2009 - academic.oup.com
In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …
detected and some of these compounds are currently undergoing either preclinical or …
HIV disease: fallout from a mucosal catastrophe?
JM Brenchley, DA Price, DC Douek - Nature immunology, 2006 - nature.com
The pathogenesis of human immunodeficiency virus has long been thought to center on a
gradual depletion of CD4+ T cells, with an average of 100 cells lost per microliter of blood …
gradual depletion of CD4+ T cells, with an average of 100 cells lost per microliter of blood …
[HTML][HTML] Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
F Hladik, P Sakchalathorn, L Ballweber, G Lentz… - Immunity, 2007 - cell.com
Understanding the initial events in the establishment of vaginal human immunodeficiency
virus type-1 (HIV-1) entry and infection has been hampered by the lack of appropriate …
virus type-1 (HIV-1) entry and infection has been hampered by the lack of appropriate …
Perils at mucosal front lines for HIV and SIV and their hosts
AT Haase - Nature Reviews Immunology, 2005 - nature.com
HIV-1 and simian immunodeficiency virus (SIV), as well as their hosts, face perils at mucosal
front lines in early infection. At these sites,'resting'CD4+ memory T cells fuel infection …
front lines in early infection. At these sites,'resting'CD4+ memory T cells fuel infection …
Emerging nanotechnology approaches for HIV/AIDS treatment and prevention
T Mamo, EA Moseman, N Kolishetti… - …, 2010 - Taylor & Francis
Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination
antiretroviral therapy has dramatically improved treatment, but it has to be taken for a …
antiretroviral therapy has dramatically improved treatment, but it has to be taken for a …
Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
BR O'Keefe, F Vojdani, V Buffa… - Proceedings of the …, 2009 - National Acad Sciences
To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides
are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal …
are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal …