Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by
inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This …

Determination of glomerular filtration rate (GFR) in conscious mice is cumbersome for the
experimenter and stressful for the animals. Here we report on a simple new technique …

Background Hematologic and biochemical analytes of Sprague-Dawley rats are commonly
used to determine effects that were induced by treatment and to evaluate organ dysfunction …

Ischemic preconditioning (IPC) is a potent renoprotective strategy which has not yet been
translated successfully into clinical practice, in spite of promising results in animal studies …

Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult
population in developed countries. In patients with CKD adequate renal clearance is …

Transdermal analysis of glomerular filtration rate (GFR) is an established technique that is
used to assess renal function in mouse and rat models of acute kidney injury and chronic …

Levels of the necessary nutrient vitamin C (ascorbate) are tightly regulated by intestinal
absorption, tissue accumulation, and renal reabsorption and excretion. Ascorbate levels are …

Purpose: Knowledge of transporters responsible for the renal secretion of creatinine is key to
a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal …