Heparin mimetics are synthetic and semi-synthetic compounds that are highly sulfated,
structurally distinct analogues of glycosaminoglycans. These mimetics are often rationally …

The chapter will review early and more recent seminal contributions to the discovery and
characterization of heparanase and non-anticoagulant heparins inhibiting its peculiar …

In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is
associated with cell-surface and extracellular matrix remodeling as well as the release of HS …

Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase
enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment …

AIM To detect the mechanisms of Helicobacter pylori (H. pylori) infection in the invasion and
metastasis of gastric cancer (GC). METHODS Specimens from 99 patients with GC were …

Introduction Gastric cancer (GC) has the higher genetic, cytologic, and architectural
heterogeneity compared to other gastrointestinal cancers. By inducing gastric inflammation …

Highlights•The anticoagulant heparin also has anti-inflammatory and anti-metastatic
properties.•Pre-clinical studies indicate the potential of heparin in lung disorders and …

Non-anticoagulant biological functions of heparin-based drugs have drawn increasing
attention. However, the exploration into the non-anticoagulant activities of various low …

Heparanase is the only known endo-β-glucuronidase able to cleave heparan sulfate,
participating in degradation and remodelling of the extracellular matrix. Heparanase …

Researchers are paying increasing attention to the strongly negatively charged
heteropolysaccharides in cells, in the extracellular matrix or in the cell wall. Examples of …