Meta-analysis of genome-wide association studies (GWASs) has become a popular method
for discovering genetic risk variants. Here, we overview both widely applied and newer …

The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Correctable weaknesses in the design, conduct, and analysis of biomedical and public
health research studies can produce misleading results and waste valuable resources …

Newly discovered true (non-null) associations often have inflated effects compared with the
true effect sizes. I discuss here the main reasons for this inflation. First, theoretical …

Advances in genomics have led to mounting expectations in regard to their impact on health
care and disease prevention. In light of this fact, a comprehensive research agenda is …

Established guidelines for causal inference in epidemiological studies may be inappropriate
for genetic associations. A consensus process was used to develop guidance criteria for …

Background Robust replication is a sine qua non for the rigorous documentation of
proposed associations in the genome-wide association (GWA) setting. Currently …

Studies using genome-wide platforms have yielded an unprecedented number of promising
signals of association between genomic variants and human traits. This Review addresses …

Recent emphasis on translational research (TR) is highlighting the role of epidemiology in
translating scientific discoveries into population health impact. The authors present …

The advent of genome-wide association studies has allowed considerable progress in the
identification and robust replication of common gene variants that confer susceptibility to …