Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

N 6-Methyladenosine (m 6 A), the most prevalent internal modification associated with
eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export …

Objective The aim of the study was to investigate the role and regulatory mechanisms of
fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

RNA methylation is an important epigenetic modification. Recent studies on RNA
methylation mainly focus on the m6A modification of mRNA, but very little is known about the …

p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

Modifications in mRNA constitute ancient mechanisms to regulate gene expression post-
transcriptionally. N 6-methyladenosine (m 6 A) is the most prominent mRNA modification …

RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …