The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to
the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of …

Dyslipidemia and inflammation are well known causal risk factors the development of
atherosclerosis. The interplay between lipid metabolism and inflammation at multiple levels …

This article provides a comprehensive review about the molecular and metabolic actions of
PPAR-α. It describes its structural features, ligand specificity, gene transcription …

Peroxisome proliferator‐activated receptors (PPARs) are a group of nuclear receptors that
function as transcription factors regulating the expression of numerous target genes. PPARs …

MicroRNAs (miRs) hybridize with complementary sequences in mRNA and silence genes by
destabilizing mRNA or preventing translation of mRNA. Over 60% of human protein-coding …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Obesity-related hypertension has become an epidemic health problem and a major risk
factor for the development of cardiovascular disease (CVD). Recent research on the …

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from
Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20 (S)-ginsenoside Rg3 …

Metabolic syndrome (MetS) is a constellation of risk factors including insulin resistance,
central obesity, dyslipidemia and hypertension that markedly increase the risk of Type 2 …