Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …

Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …

Histone modifications influence higher-order chromatin structures at individual epigenomic
states and chromatin environments to regulate gene expression. However, genome-wide …

Chromatin organization over multiple length scales plays a critical role in the regulation of
transcription. Deciphering the interplay of these processes requires high-resolution, three …

While major changes in cellular morphology during apoptosis have been well described, the
subcellular changes in nuclear architecture involved in this process remain poorly …

In eukaryotic cells, highly condensed inactive/silenced chromatin has long been called
“heterochromatin.” However, recent research suggests that such regions are in fact not fully …

While various cell responses on material surfaces have been examined, relatively few
reports are focused on significant self-deformation of cell nuclei and corresponding …

Abstract 4D nucleome research aims to understand the impact of nuclear organization in
space and time on nuclear functions, such as gene expression patterns, chromatin …

Polycomb group (PcG) proteins silence master regulatory genes required to properly confer
cell identity during the development of both Drosophila and mammals. They may act through …