Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Predicting disease-related long non-coding RNAs (lncRNAs) is beneficial to finding of new
biomarkers for prevention, diagnosis and treatment of complex human diseases. In this …

Branched-chain amino acids (BCAAs) are essential amino acids in human bodies. They
have complex metabolic pathways and various metabolites. Both BCAAs and its metabolites …

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer
development and progression, including the metastatic spread of disease. Through in silico …

Abstract Model selection is an important issue in support vector machine-based recursive
feature elimination (SVM-RFE). However, performing model selection on a linear SVM-RFE …

Abstract Purpose: Extramammary Paget disease (EMPD) is an uncommon skin malignancy
whose genetic alterations are poorly characterized. Previous reports identified mutations in …

Breast cancer is the second most common malignancy, worldwide. Treatment decisions are
based on tumor stage, histological subtype, and receptor expression and include …

By establishing multi-omics pipelines, we uncover overexpression and gene copy-number
alterations of nucleoporin-93 (NUP93), a nuclear pore component, in aggressive human …

The accumulation of somatic mutations in healthy human tissues has been extensively
characterized, but the mutational landscape of the healthy breast is still poorly understood …