Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …

A complete anatomical analysis of central cholinergic systems is currently possible as a
result of the development of very sensitive immunohistochemical methods. Viewed in their …

Importance Nerve growth factor (NGF) is an endogenous neurotrophic factor that prevents
the death and augments the functional state of cholinergic neurons of the basal forebrain, a …

Brain-derived neurotrophic factor (BDN F) was found to promote the survival of E17 rat
embryo septal cholinergic neurons in culture, as assessed by a histochemical stain for …

In addition to their role in cellular metabolic activity, thyroid hormones (THs), also regulate
neural development; the central nervous system is particularly dependent on TH for normal …

The survival, differentiation, and maintenance of responsive neurons are regulated by nerve
growth factor (NGF), which is secreted by the target and interacts with receptors on the axon …

The endosome/lysosome pathway is disrupted early in the course of both Alzheimer's
disease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this …

Programmed cell death (apoptosis) is a normal process in the developing nervous system.
Recent data suggest that certain features seen in the process of programmed cell death may …

Although the interest in the septohippocampal (SH) pathway is not recent [see the series of
papers by Petsche and co-workers in the 1960s (436, 437)], its study has been hampered for …

Neurotrophin nerve growth factor (NGF) has been suggested to be involved in age-related
neurodegenerative diseases, but no transgenic model is currently available to study this …