Targeting cardiac stem cell senescence to treat cardiac aging and disease
E Cianflone, M Torella, F Biamonte, A De Angelis… - Cells, 2020 - mdpi.com
Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …
From spheroids to organoids: the next generation of model systems of human cardiac regeneration in a dish
Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …
the differentiation of stem cells. The growing interest in the use of organoids arises from their …
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice
Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
Physical exercise and cardiac repair: the potential role of nitric oxide in boosting stem cell regenerative biology
Over the years strong evidence has been accumulated showing that aerobic physical
exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk …
exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk …
Unraveling and targeting myocardial regeneration deficit in diabetes
Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction
without coronary atherosclerosis and hypertension is driven by hyperglycemia …
without coronary atherosclerosis and hypertension is driven by hyperglycemia …
Unravelling the biology of adult cardiac stem cell-derived exosomes to foster endogenous cardiac regeneration and repair
Cardiac remuscularization has been the stated goal of the field of regenerative cardiology
since its inception. Along with the refreshment of lost and dysfunctional cardiac muscle cells …
since its inception. Along with the refreshment of lost and dysfunctional cardiac muscle cells …
Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age
Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells
(CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence …
(CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence …
Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification
Background: Three-dimensional cell culture systems hold great promise for bridging the gap
between in vitro cell-based model systems and small animal models to study tissue biology …
between in vitro cell-based model systems and small animal models to study tissue biology …
Cardiac stem cell-loaded delivery systems: a new challenge for myocardial tissue regeneration
Cardiovascular disease (CVD) remains the leading cause of death in Western countries.
Post-myocardial infarction heart failure can be considered a degenerative disease where …
Post-myocardial infarction heart failure can be considered a degenerative disease where …
In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes
Abstract miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …