Agent-based methods facilitate integrative science in cancer
In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …
Mutant clones in normal epithelium outcompete and eliminate emerging tumours
Human epithelial tissues accumulate cancer-driver mutations with age,,,,,,,–, yet tumour
formation remains rare. The positive selection of these mutations suggests that they alter the …
formation remains rare. The positive selection of these mutations suggests that they alter the …
A scarless healing tale: comparing homeostasis and wound healing of oral mucosa with skin and oesophagus
D Pereira, I Sequeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
During aging, progenitor cells acquire mutations, which may generate clones that colonize
the surrounding tissue. By middle age, normal human tissues, including the esophageal …
the surrounding tissue. By middle age, normal human tissues, including the esophageal …
Selection of oncogenic mutant clones in normal human skin varies with body site
Skin cancer risk varies substantially across the body, yet how this relates to the mutations
found in normal skin is unknown. Here we mapped mutant clones in skin from high-and low …
found in normal skin is unknown. Here we mapped mutant clones in skin from high-and low …
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …
Outcompeting p53-mutant cells in the normal esophagus by redox manipulation
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of
mutant clones. Some mutations are under positive selection, conferring a competitive …
mutant clones. Some mutations are under positive selection, conferring a competitive …
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of
most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost …
most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost …
Somatic mutation: what shapes the mutational landscape of normal epithelia?
JC Fowler, PH Jones - Cancer discovery, 2022 - AACR
Epithelial stem cells accumulate mutations throughout life. Some of these mutants increase
competitive fitness and may form clones that colonize the stem cell niche and persist to …
competitive fitness and may form clones that colonize the stem cell niche and persist to …
Lineage tracing in human tissues
The dynamical process of cell division that underpins homeostasis in the human body
cannot be directly observed in vivo, but instead is measurable from the pattern of somatic …
cannot be directly observed in vivo, but instead is measurable from the pattern of somatic …