In the last decade, B 12-dependent radical SAM enzymes have emerged as central
biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes …

Soil microbial communities impact carbon sequestration and release, biogeochemical
cycling, and agricultural yields. These global effects rely on metabolic interactions that …

Cobalamin (Vitamin B 12) is a cofactor for many enzymes, including those in bacteria,
archaea, algae, and mammals. In humans, cobalamin deficiency can lead to pernicious …

Soil microbial communities perform critical ecosystem services through the collective
metabolic activities of numerous individual organisms. Most microbes use corrinoids, a …

Bacteria encounter chemically similar nutrients in their environment, which impact their
growth in distinct ways. Among such nutrients are cobamides, the structurally diverse family …

To produce the health-associated metabolite propionate, gut microbes require vitamin B12
as a cofactor to convert succinate to propionate. B12 is sourced in the human gut from the …

The draft genome sequence of the soil bacterium Pedococcus sp. strain 5OH_020, isolated
on a natural cobalamin analog, comprises 4.4 Mbp, with 4,108 protein-coding genes. Its …

Soil microbial communities perform critical ecosystem services through the collective
metabolic activities of numerous individual organisms. Most microbes use corrinoids, a …

Soil not only represents the physical surface of the earth, but is also a habitat for thousands
of species of microorganisms. Numerous species of bacteria and other microbes collectively …