HOX genes encode an evolutionarily conserved set of transcription factors that control how
the phenotype of an organism becomes organized during development based on its genetic …

Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated
nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' …

HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …

Background: Acute myeloid leukemia (AML) is a malignant hematological disease,
originating from hematopoiesis stem cell differentiation obstruction and clonal proliferation …

Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and
disease. However, whether these elements are induced by oncogenes and can regulate …

Most transcription factors were for a long time considered as undruggable targets because
of the absence of binding pockets for direct targeting. HOXA9, implicated in acute myeloid …

Self-renewing somatic tissues rely on progenitors to support the continuous tissue
regeneration. The gene regulatory network maintaining progenitor function remains …

The HOXA gene cluster is generally recognized as a pivotal mediator of positional identity in
the skeletal system, expression of different orthologues conferring alternative locational …

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia
(AML) in which leukemic blasts have megakaryocytic features. AMKL makes up 4%–15% of …