Fitness Landscapes and Evolution of Catalytic RNA

R Saha, A Vázquez-Salazar, A Nandy… - Annual Review of …, 2024 - annualreviews.org
The relationship between genotype and phenotype, or the fitness landscape, is the
foundation of genetic engineering and evolution. However, mapping fitness landscapes …

Aurora: a fluorescent deoxyribozyme for high-throughput screening

M Volek, J Kurfürst, M Drexler, M Svoboda… - Nucleic Acids …, 2024 - academic.oup.com
Fluorescence facilitates the detection, visualization, and tracking of molecules with high
sensitivity and specificity. A functional DNA molecule that generates a robust fluorescent …

Apollon: a deoxyribozyme that generates a yellow product

M Volek, J Kurfürst, M Kožíšek, P Srb… - Nucleic Acids …, 2024 - academic.oup.com
Colorimetric assays in which the color of a solution changes in the presence of an input
provide a simple and inexpensive way to monitor experimental readouts. In this study we …

Development and use of deoxyribozymes that generate color and fluorescence

M Volek - 2024 - dspace.cuni.cz
The recent SARS-CoV-2 pandemic showed how humanity can be threatened by organisms
as simple as viruses. This crisis emphasized the need for timely and reliable diagnostics, as …