Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Almost 20% of COVID-19 patients have a history of atrial fibrillation (AF), but also a new-
onset AF represents a frequent complication in COVID-19. Clinical evidence demonstrates …

The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not
known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that …

A wide range of atrial arrythmias are caused by molecular defects in proteins that regulate
calcium (Ca) cycling. In many cases, these defects promote the propagation of subcellular …

Atrial fibrillation (AF) is the most common heart rhythm disorder and a major cause of stroke.
Unfortunately, current therapies for AF are suboptimal, largely because the molecular …

It is well known that heart failure (HF) typically coexists with atrial fibrillation (AF). However,
until now, no clear mechanism has been established that relates HF to AF. In this study, we …

The goal of this work was to investigate the role of t-tubule (TT) remodeling in abnormal
Ca2+ cycling in ventricular myocytes of failing dog hearts. Heart failure (HF) was induced …