Coenzyme A biosynthesis: an antimicrobial drug target

C Spry, K Kirk, KJ Saliba - FEMS microbiology reviews, 2008 - academic.oup.com
Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic
microorganisms. Since the structure of pantothenic acid was determined, many analogues of …

Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803

LA Mills, AJ McCormick, DJ Lea-Smith - Bioscience reports, 2020 - portlandpress.com
Cyanobacteria are key organisms in the global ecosystem, useful models for studying
metabolic and physiological processes conserved in photosynthetic organisms, and …

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes

R Overbeek, T Begley, RM Butler… - Nucleic acids …, 2005 - academic.oup.com
The release of the 1000th complete microbial genome will occur in the next two to three
years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) …

[图书][B] Handbook of vitamins

J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Biosynthesis of pantothenic acid and coenzyme A

R Leonardi, S Jackowski - EcoSal Plus, 2007 - Am Soc Microbiol
Pantothenate is vitamin B5 and is the key precursor for the biosynthesis of coenzyme A
(CoA), a universal and essential cofactor involved in a myriad of metabolic reactions …

Inhibiting bacterial fatty acid synthesis

YM Zhang, SW White, CO Rock - Journal of Biological Chemistry, 2006 - ASBMB
The type II fatty acid synthase consists of a series of individual enzymes, each encoded by a
separate gene, that catalyze discrete steps in chain elongation. The formation of fatty acids …

Integrative chemical and multiomics analyses of tetracycline removal mechanisms in Pseudomonas sp. DX-21

M Yang, Y Ma, X Song, J Miao, L Yan - Journal of Hazardous Materials, 2024 - Elsevier
Tetracycline (TC), widely found in various environments, poses significant risks to
ecosystems and human health. While efficient biodegradation removes TC, the mechanisms …

Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification

JL Meier, AC Mercer, H Rivera… - Journal of the American …, 2006 - ACS Publications
In vivo carrier protein tagging has recently become an attractive target for the site-specific
modification of fusion systems and new approaches to natural product proteomics. A …

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

LE de Vries, M Lunghi, A Krishnan, TWA Kooij… - PLoS …, 2021 - journals.plos.org
The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Enhancement of fatty acid biosynthesis by exogenous acetyl-CoA carboxylase and pantothenate kinase in Escherichia coli

S Satoh, M Ozaki, S Matsumoto, T Nabatame… - Biotechnology …, 2020 - Springer
Objectives To establish a technique for efficient fatty acid production through enhancement
of coenzyme A (CoA) biosynthesis and malonyl-CoA supply by introducing exogenous …