Polymersome-based protein drug delivery–quo vadis?

MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

Polymersomes for therapeutic delivery of protein and nucleic acid macromolecules: from design to therapeutic applications

S Iqbal, M Blenner, A Alexander-Bryant… - …, 2020 - ACS Publications
Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal
antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential …

Recent advances in permeable polymersomes: fabrication, responsiveness, and applications

Y Zhu, S Cao, M Huo, JCM van Hest, H Che - Chemical science, 2023 - pubs.rsc.org
Polymersomes are vesicular nanostructures enclosed by a bilayer-membrane self-
assembled from amphiphilic block copolymers, which exhibit higher stability compared with …

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

S Cao, J Shao, LKEA Abdelmohsen… - Aggregate, 2022 - Wiley Online Library
Aggregation‐induced emission (AIE) is a phenomenon in which fluorescence is enhanced
rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible …

Dynamic metastable polymersomes enable continuous flow manufacturing

CK Wong, RY Lai, MH Stenzel - Nature Communications, 2023 - nature.com
Polymersomes are polymeric analogues of liposomes with exceptional physical and
chemical properties. Despite being dubbed as next-generation vesicles since their inception …

Macromolecular design and preparation of polymersomes

J Lefley, C Waldron, CR Becer - Polymer Chemistry, 2020 - pubs.rsc.org
From drug delivery to nanoreactors and protocells, polymersomes have gained
considerable interest from researchers due to their novel applications. However, one of the …

Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution

SDP Fielden - Journal of the American Chemical Society, 2024 - ACS Publications
Covalent polymers are versatile macromolecules that have found widespread use in society.
Contemporary methods of polymerization have made it possible to construct sequence …

Complex energy landscapes of self-assembled vesicles

J Luan, D Wang, S Zhang, Y Miyazaki… - Journal of the …, 2023 - ACS Publications
The field of supramolecular chemistry has witnessed tremendous progress in bringing the
system away from equilibrium for traditionally inaccessible structures and functions …

Emerging trends in solution self-assembly of block copolymers

Z Deng, S Liu - Polymer, 2020 - Elsevier
Since the foundation of macromolecular science by Staudinger, advances in polymer
chemistry have unveiled enormous avenues for controlling chemical structures at the …

Corona-loading strategies for crystalline particles made by living crystallization-driven self-assembly

S Ganda, CK Wong, MH Stenzel - Macromolecules, 2021 - ACS Publications
Self-assembled block copolymer (BCP) nanoparticles offer exciting opportunities for drug
delivery applications. A key feature of using BCP nanoparticles for drug delivery is their …