INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

In vitro selection technology has transformed the development of therapeutic monoclonal
antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders …

Infants and young children are more susceptible to common respiratory pathogens than
adults but can fare better against novel pathogens like severe acute respiratory syndrome …

Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is
approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the …

With the advent of high-throughput sequencing of immunoglobulin genes (Ig-Seq), the
understanding of antibody repertoires and their dynamics among individuals and …

B-cell responses result in clonal expansion, and can occur in a variety of tissues. To define
how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages …

Background Immune-mediated protection is mediated by T cells expressing pathogen-
specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as …

Motivation T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive
immune system by recognizing an enormous variety of external and internal antigens …

The persistence of anti-viral immunity is essential for protection and exhibits profound
heterogeneity across individuals. Here, we elucidate the factors that shape maintenance …