Could 3D models of cancer enhance drug screening?
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
Biomaterials and 3D bioprinting strategies to model glioblastoma and the blood–brain barrier
Glioblastoma (GBM) is the most prevalent and lethal adult primary central nervous system
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
Three‐dimensional cell culture models for anticancer drug screening: Worth the effort?
ET Verjans, J Doijen, W Luyten… - Journal of cellular …, 2018 - Wiley Online Library
High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
Evolution of experimental models in the study of glioblastoma: toward finding efficient treatments
R Gómez-Oliva, S Domínguez-García… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …
[HTML][HTML] Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling
N Chaicharoenaudomrung, P Kunhorm… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells
RD Carruthers, SU Ahmed, S Ramachandran… - Cancer research, 2018 - AACR
Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …
[HTML][HTML] Glutamatergic mechanisms in glioblastoma and tumor-associated epilepsy
F Lange, MF Hörnschemeyer, T Kirschstein - Cells, 2021 - mdpi.com
The progression of glioblastomas is associated with a variety of neurological impairments,
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …
Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy
Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …
Decellularized tissues as platforms for in vitro modeling of healthy and diseased tissues
Biomedical engineers are at the forefront of developing novel treatments to improve human
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …