Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals

M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

An outlook on permeability escalation through cocrystallization for developing pharmaceuticals with improved biopharmaceutical properties

N Pandey, A Ghosh - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Permeability of any pharmaceutical is critically significant for its biopharmaceutical profile,
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …

Enhanced phytoremediation of Metal (loid) s via spiked ZVI nanoparticles: An urban clean-up strategy with ornamental plants

A Majumdar, MK Upadhyay, M Ojha, F Afsal, B Giri… - Chemosphere, 2022 - Elsevier
The increasing industrialization and urbanization are also triggering environmental
pollution, mostly unnoticed, in the case of soil pollution due to uncontrolled contamination by …

Progress on cocrystallization of poorly soluble NME's in the last decade

P Roy, A Ghosh - CrystEngComm, 2020 - pubs.rsc.org
For tailoring the physicochemical properties of active pharmaceutical ingredients,
cocrystallization has been an exciting field of interest to the researchers. As in recent years …

Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and …

FZ Bu, YM Yu, M Zhang, CW Yan, ZY Wu… - Crystal Growth & …, 2023 - ACS Publications
To achieve new breakthroughs in the development of synergistic antiviral medication
cocrystals of acyclovir (AYL) with phenolic acids, a cocrystallization-driven strategy for …

Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions

J Li, X Wang, D Yu, Y Zhoujin, K Wang - International Journal of …, 2023 - Elsevier
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …

Challenges and progress in nonsteroidal anti-inflammatory drugs co-crystal development

I Nugrahani, RD Parwati - Molecules, 2021 - mdpi.com
Co-crystal innovation is an opportunity in drug development for both scientists and industry.
In line with the “green pharmacy” concept for obtaining safer methods and advanced …

Novel drug-drug salts of enoxacin with enhanced antibacterial activity: Insights from solubility and lipid-water partition coefficient

J Li, S Song, W Huang, H Fan, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Enoxacin (ENX), a third-generation fluoroquinolone, demonstrates broad-spectrum
antibacterial activities and is widely applied for the treatment of various bacterial infections …

Cocrystallization of trimethoprim and solubility enhancement via salt formation

Q Zheng, DK Unruh, KM Hutchins - Crystal Growth & Design, 2021 - ACS Publications
Trimethoprim (TMP) is an active pharmaceutical ingredient with poor aqueous solubility.
Here, we describe the cocrystallization of TMP with five co-formers, three bipyridines and …

Cocrystallization-driven double-optimized stratagem toward directional self-assembly for the first ternary salt cocrystal of cardiotonic drug milrinone with different …

SS Meng, YM Yu, FZ Bu, CW Yan, ZY Wu… - Molecular …, 2023 - ACS Publications
The current research leverages the structural features and property superiorities along with
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …