The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Epidemiological data suggest that early life exposures are key determinants of immune-
mediated disease later in life. Young children are also particularly susceptible to infections …

There is considerable heterogeneity in immunological parameters between individuals, but
its sources are largely unknown. To assess the relative contribution of heritable versus non …

Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or
persistent infections of the skin, nails, and oral and genital mucosae caused by Candida …

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal
dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here …

Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Background Deep dermatophytosis is a severe and sometimes life-threatening fungal
infection caused by dermatophytes. It is characterized by extensive dermal and …

ISG15 is an interferon (IFN)-α/β–inducible, ubiquitin-like intracellular protein. Its conjugation
to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe …