Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of
the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal …

The R-spondin protein family comprises four members (RSPO1-4), which are agonists of the
canonical Wnt/β-catenin pathway. Emerging evidence revealed that RSPOs should not only …

Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche,
have remarkable regenerative capacity throughout hair cycling, and display fate plasticity …

Classic hormone membrane receptors, such as leucine-rich repeat-containing G protein–
coupled receptor (LGR) 1 (follicle-stimulating hormone receptor), LGR2 (luteinizing hormone …

Rhubarb, the rhizome and root of Rheum palmatum L. from the Polygonaceae family, is a
globally important medicinal plant, especially in eastern Asia. It has been indicated for …

Although the role of the transcription factor NF-κB in intestinal inflammation and tumor
formation has been investigated extensively, a physiological function of NF-κB in sustaining …

Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in
the bone marrow (BM). Previously, it was reported that G-protein-coupled receptor 4 (LGR4) …

Objective Loss of functional β-cell mass is a major cause of diabetes. Thus, identifying
regulators of β-cell health is crucial for treating this disease. The Leucine-rich repeat …

The leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) belonging to G
protein-coupled receptors (GPCRs) family, had various regulatory roles at multiple cellular …

Background Sepsis is a major cause of in-hospital death, particularly in the intensive care
unit. A huge amount of effort has been put into identifying reliable biomarkers to improve the …