Work in large part on Leishmania major in the 1980s identified two distinct apparently
counter-regulatory CD4+ T cell populations, T helper (h) 1 and Th2, that controlled …

Human visceral leishmaniasis (HVL) is the most severe clinical form of a spectrum of
neglected tropical diseases caused by protozoan parasites of the genus Leishmania …

Background/Purpose Leishmania (L.) tropica is the causative agent of different forms of
human leishmaniasis. There is little information about the role of Leishmania-specific …

It has been tested and proven that vaccination is still the best strategy to combat infectious
diseases. However, to date, there are still no vaccines against human soil-transmitted …

In the murine model of Leishmania major infection, resistance or susceptibility to the parasite
has been associated with the development of a Th1 or Th2 type of immune response …

In schistosomiasis patients, parasite eggs trapped in hepatic sinusoids become foci for
CD4+ T cell-orchestrated granulomatous cellular infiltrates. Since the immune response is …

Previously, we showed that genetically modified live-attenuated Leishmania donovani
parasite cell lines (LdCen−/− and Ldp27−/−) induce a strong cellular immunity and provide …

Visceral leishmaniasis (VL) has a high fatality rate if not treated; nevertheless, the majority of
human infections with the causative agent, Leishmania infantum chagasi, are asymptomatic …

Intracellular pathogen‐specific antibodies (Abs) can contribute to host protection by a
number of different mechanisms. Ab opsonization of pathogens residing outside a host cell …

Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis
(CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis …