An assessment of EGFR and HER2 inhibitors with structure activity relationship of fused pyrimidine derivatives for breast cancer: a brief review
Epidermal growth factor receptor (EGFR) and its subtype human epidermal growth factor
receptor 2 (HER2) gets activated when its endogenous ligand (s) bind to its ATP binding site …
receptor 2 (HER2) gets activated when its endogenous ligand (s) bind to its ATP binding site …
Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors
Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …
Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo [3, 2-a] pyrimidines
NS El-Sayed, ER El-Bendary, SM El-Ashry… - European journal of …, 2011 - Elsevier
New series of sulfonamide derivatives of [1, 3, 4] thiadiazolo [3, 2-a] pyrimidine were
synthesized and investigated as antitumor agents. Some of the newly prepared compounds …
synthesized and investigated as antitumor agents. Some of the newly prepared compounds …
Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer …
MAE Mourad, A Abo Elmaaty, I Zaki… - Journal of Enzyme …, 2023 - Taylor & Francis
Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical
DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in …
DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in …
Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole
D Seenaiah, PR Reddy, GM Reddy, A Padmaja… - European Journal of …, 2014 - Elsevier
A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio,
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents
PC Lv, DD Li, QS Li, X Lu, ZP Xiao, HL Zhu - Bioorganic & medicinal …, 2011 - Elsevier
Fourty-two thiazolyl-pyrazoline derivatives were synthesized to screen for their EGFR kinase
inhibitory activity. Compound 4-(4-chlorophenyl)-2-(3-(3, 4-dimethylphenyl)-5-p-tolyl-4, 5 …
inhibitory activity. Compound 4-(4-chlorophenyl)-2-(3-(3, 4-dimethylphenyl)-5-p-tolyl-4, 5 …
Design and synthesis of novel Thiazolo [5, 4-b] pyridine derivatives as potent and selective EGFR-TK inhibitors targeting resistance mutations in non-small cell lung …
AS Borude, SR Deshmukh, SV Tiwari, SH Kumar… - European Journal of …, 2024 - Elsevier
A novel series of substituted thiazolo [5, 4-b] pyridine analogues were rationally designed
and synthesized via a multi-step synthetic pathway, including Suzuki cross-coupling …
and synthesized via a multi-step synthetic pathway, including Suzuki cross-coupling …
Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines
NR Kamdar, DD Haveliwala, PT Mistry… - European journal of …, 2010 - Elsevier
The clinical significance of pyran and pyrimidine condensed systems and the raise in
problem of multidrug resistant bacterial pathogens has directed us to synthesize …
problem of multidrug resistant bacterial pathogens has directed us to synthesize …
Gefitinib derivatives and drug-resistance: A perspective from molecular dynamics simulations
A Ahmadi, E Mohammadnejadi… - Computers in Biology and …, 2023 - Elsevier
Epidermal-growth factor receptor (EGFR) is a transmembrane tyrosine kinase (TK) with a
significant role in cell survival. EGFR is upregulated in various cancer cells and known as a …
significant role in cell survival. EGFR is upregulated in various cancer cells and known as a …
An efficient one-pot three-component synthesis of functionalized pyrimido [4, 5-b] quinolines and indeno fused pyrido [2, 3-d] pyrimidines in water
A simple, efficient, and high yielding one-pot protocol for the synthesis of pyrimido [4, 5-b]
quinolines and indeno [2′, 1′: 5, 6] pyrido [2, 3-d] pyrimidines has been developed by …
quinolines and indeno [2′, 1′: 5, 6] pyrido [2, 3-d] pyrimidines has been developed by …