Mammalian Krüppel-like factors in health and diseases
BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
The changing role of TGFβ in healthy, ageing and osteoarthritic joints
PM Van Der Kraan - Nature Reviews Rheumatology, 2017 - nature.com
Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the
regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has …
regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has …
The roles and regulation of the KLF5 transcription factor in cancers
Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …
that KLF5 regulates the expression of a large number of new target genes and participates …
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …
number of gene promoters and regulating their transcription. KLF5 is expressed during …
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …
very limited and the underlying mechanisms are poorly understood. We report that bone …
Feedback regulation of TGF-β signaling
X Yan, X Xiong, YG Chen - Acta biochimica et biophysica Sinica, 2018 - academic.oup.com
Transforming growth factor beta (TGF-β) is a multi-functional polypeptide that plays a critical
role in regulating a broad range of cellular functions and physiological processes. Signaling …
role in regulating a broad range of cellular functions and physiological processes. Signaling …
[HTML][HTML] Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …
continue to proliferate, cancer cells must somehow uncouple themselves from the many …
Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts
Inactivation of phosphatase and tensin homolog (PTEN) is prevalent in human prostate
cancer and causes high-grade adenocarcinoma with a long latency. Cancer-associated …
cancer and causes high-grade adenocarcinoma with a long latency. Cancer-associated …
Myosin II isoform switching mediates invasiveness after TGF-β–induced epithelial–mesenchymal transition
Despite functional significance of nonmuscle myosin II in cell migration and invasion, its role
in epithelial–mesenchymal transition (EMT) or TGF-β signaling is unknown. Analysis of …
in epithelial–mesenchymal transition (EMT) or TGF-β signaling is unknown. Analysis of …
The complex biology of FOXO
M Monsalve, Y Olmos - Current drug targets, 2011 - ingentaconnect.com
FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic
processes. Loss of FOXO function has been identified in several human cancers, and results …
processes. Loss of FOXO function has been identified in several human cancers, and results …