Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

Signal transducer and activator of transcription (STAT) proteins are critical mediators of
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers
of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible …

Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …

Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …

Suppression of nascent DNA degradation has emerged as an essential role of the BRCA
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …

Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and
evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the …

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

Abstract Poly (ADP-ribose) polymerases (PARPs) are NAD+ dependent enzymes that were
identified as DNA repair proteins, however, today it seems clear that PARPs are responsible …