Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with
no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours …

The management of intracranial germ-cell tumours is complex because of varied clinical
presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary …

Abstract Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours
where needle biopsies help guide diagnosis and targeted therapies. To address spatial …

Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid
glial neoplasms of the thalamus or brainstem that typically arise in young children and are …

Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of
consistent, objective disease assessments and standardised response criteria. The …

Brain tumors are the most common solid tumors in the pediatric population. Pediatric neuro-
oncology has changed tremendously during the past decade owing to ongoing genomic …

Background: Diffuse Intrinsic Pontine Glioma (DIPG) is the leading cause of brain tumor-
related death in children, with median survival of less than one year. Despite decades of …

Background Activation of the mammalian target of rapamycin (mTOR) pathway is observed
in neurofibromatosis type 1 (NF1) associated low-grade gliomas (LGGs), but agents that …

Abstract pLGGs are a group of tumors for which the era of molecular diagnostics has truly
shifted treatment paradigms and patient care. The discovery that this group of tumors is …

Diffuse intrinsic pontine glioma (DIPG) is a disease of childhood whose abysmal prognosis
has remained unchanged for over 50 years. Biologic investigation has been stymied by lack …