For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the
function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar …

Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …

Several lines of evidence have suggested for decades a role for norepinephrine (NE) in the
pathophysiology and treatment of schizophrenia. Recent experimental findings reveal …

Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …

Trace amines, a group of amines expressed at the nanomolar level in the mammalian brain,
can modulate monoamine transmission. The discovery of and the functional research on the …

Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but
the mechanisms of these deficits are unknown. Genomic association studies have …