Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …

During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

Epilepsy is a common neurological disease in both humans and domestic dogs, making
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …

Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur
at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence …

Abstract Neuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic
heritable autism spectrum disorder (ASD) and cause alterations in both synaptic and …

Chronic exposure to addictive drugs in substance use disorders and stressors in mood
disorders render the brain more vulnerable to inflammation. Inflammation in the brain, or …

The quantitative relationship between the disruption of the blood-brain barrier (BBB) and the
recruitment of glial cells was explored in a mouse model of endotoxemia.[18F] 2-Fluoro-2 …

Maternal infection during pregnancy and childhood social trauma have been associated
with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum …

Multiple sclerosis (MS) is a progressive and inflammatory demyelinating disease of the CNS.
Peroxisomes perform critical functions that contribute to CNS homeostasis. We investigated …

The rapid and continual development of a number of radiopharmaceuticals targeting
different receptor, enzyme and small molecule systems has fostered Positron Emission …