Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Tripartite motif (TRIM) proteins have been implicated in multiple cellular functions, including
antiviral activity. Research efforts so far indicate that the antiviral activity of TRIMs relies, for …

Ubiquitination is one of the posttranslational modifications that regulates a number of
intracellular events including signal transduction, protein quality control, transcription, cell …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …

Several transcriptional and epigenetic regulators have been functionally linked to the control
of viral and cellular gene expression programs. One such regulator is Krüppel-associated …

Viral latency can be considered a metastable, nonproductive infection state that is capable
of subsequent reactivation to repeat the infection cycle. Viral latent infections have …

Abstract Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin
ligases involved in different cellular functions. Of special interest are their roles in innate …

Intrinsic immunity describes the set of recently discovered but poorly understood cellular
mechanisms that specifically target viral pathogens. Their discovery derives in large part …