The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …

Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma
membrane. These close to entrap droplets of medium into micron-sized vesicles, which are …

Abstract INPP4B suppresses PI3K/AKT signaling by converting PI (3, 4) P2 to PI (3) P and
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …

Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

Macropinocytosis, an evolutionarily conserved endocytic mechanism that mediates non-
specific fluid-phase uptake, is potently upregulated by various oncogenic pathways. It is now …

Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now
report that the exogenous addition of the second messenger lipid sn-1, 2 DAG to the culture …

Wnt signaling is essential for embryonic development, influencing processes such as axis
formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also …