Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis

T Parimon, C Yao, BR Stripp, PW Noble… - International journal of …, 2020 - mdpi.com
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis

C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy

T Huang, T Zhang, X Jiang, A Li, Y Su, Q Bian… - Science …, 2021 - science.org
The transfer of mitochondria between cells has recently been revealed as a spontaneous
way to protect the injured cells. However, the utilization of this natural transfer process for …

Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage

JH Woo, HJ Seo, JY Lee, I Lee, K Jeon, B Kim… - Particle and Fibre …, 2023 - Springer
Background Polypropylene (PP) is used in various products such as disposable containers,
spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly …

RETRACTED: IL‐17A‐producing T cells exacerbate fine particulate matter‐induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR‐mediated autophagy

LH Cong, T Li, H Wang, YN Wu… - Journal of cellular …, 2020 - Wiley Online Library
Abstract Fine particulate matter (PM2. 5) is the primary air pollutant that is able to induce
airway injury. Compelling evidence has shown the involvement of IL‐17A in lung injury …

Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge

WI Effendi, T Nagano - International Journal of Molecular Sciences, 2022 - mdpi.com
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …

The impact of oxidative stress on pediatrics syndromes

G Micangeli, M Menghi, G Profeta, F Tarani, A Mariani… - Antioxidants, 2022 - mdpi.com
Oxidative stress is a condition determined by an imbalance between antioxidant and
oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed …

[HTML][HTML] SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury

D Kurundkar, AR Kurundkar, NB Bone, EJ Becker Jr… - JCI insight, 2019 - ncbi.nlm.nih.gov
Acute lung injury (ALI) is characterized by exuberant proinflammatory responses and
mitochondrial dysfunction. However, the link between mitochondrial dysfunction and …