Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

Lewy body (LB) diseases are characterized by alpha‐synuclein (AS) aggregates in the
central nervous system (CNS). Involvement of the peripheral autonomic nervous system …

It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves
and spread to the central nervous system (CNS), leading to Parkinson disease and related …

Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Progressive aggregation of alpha-synuclein (αS) through formation of amorphous pale
bodies to mature Lewy bodies or in neuronal processes as Lewy neurites may be the …

Parkinson disease (PD) is a multisystem disorder associated with α-synuclein aggregates
throughout the central, autonomic, and peripheral nervous system, clinically characterized …