Cytotoxic T lymphocytes (CTLs) have a central role in the successful control of
immunodeficiency virus infection. Evasion of this immune response through CTL escape is …

The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of
infected individuals have posed challenges to understanding the pathogenesis of HIV …

It is unclear why immunological control of HIV replication is incomplete in most infected
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …

Within-patient HIV evolution reflects the strong selection pressure driving viral escape from
cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape …

Human immunodeficiency virus (HIV)-specific T-cell responses are thought to play a key role
in viral load decline during primary infection and in determining the subsequent viral load …

Increasing evidence indicates that potent anti-HIV-1 activity is mediated by cytotoxic T
lymphocytes (CTLs),,; however, the effects of this immune pressure on viral transmission and …

Background: HLA-B57, as well as cytotoxic T-lymphocyte (CTL) responses restricted by this
allele, have been strongly associated with long-term non-progressive chronic HIV-1 …

To evaluate the impact of sustained viral loads on anti-viral T cell responses we compared
responses that cleared acute lymphocytic choriomeningitis virus infection with those that …

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below
the limit of commercial assay detection (< 50 RNA copies/ml) in the absence of antiviral …

Background Very little is known about the immunodominance patterns of HIV-1-specific T
cell responses during primary HIV-1 infection and the reasons for human lymphocyte …