The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …

The transmission of SARS‐CoV‐2 coronavirus has led to the COVID‐19 pandemic. Nucleic
acid testing while specific has limitations for mass surveillance. One alternative is the main …

In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …

Abstract Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main
protease (M pro) to cleave viral proteins. Consequently, M pro is a target for antiviral agents …

After almost two years from its first evidence, the COVID-19 pandemic continues to afflict
people worldwide, highlighting the need for multiple antiviral strategies. SARS-CoV-2 main …

This review makes a critical evaluation of 61 peer‐reviewed manuscripts that use a docking
step in a virtual screening (VS) protocol to predict SARS‐CoV‐2 M‐pro (M‐pro) inhibitors in …

Abstract Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research and antiviral
discovery are hampered by the lack of a cell-based virus replication system that can be …