The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10
people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to …

Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic
influences in human dendritic cell biology and their ability to orchestrate immune responses …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Microglial cells are the resident immune cells of the central nervous system. In the resting
state, microglia are highly dynamic and control the environment by rapidly extending and …

Drug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive
oxygen species (ROS) are master regulators of cancer development that act through …

Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …

BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …

Low response rate and treatment resistance are frequent problems in the immunotherapy of
tumors, resulting in the unsatisfactory therapeutic effects. Ferroptosis is a form of cell death …