Acute leukemias are hematologic malignancies with aggressive behavior especially in adult
population. With the introduction of new gene expression and sequencing technologies …

Breast cancer metastasis is the primary cause of mortality of patients with breast cancer. The
present study aimed to explore the role and underlying mechanisms of IGJ in the invasion …

Chimeric antigen receptor (CAR) T cell therapy has exhibited dramatic anti-tumor efficacy in
clinical trials. In this study, we reported the transcriptome profiles of bone marrow cells in …

Uncontrolled Wnt signaling causes leukemia. Inactivation of Wnt antagonists could play an
important role in leukemia progression by activating the Wnt/β-catenin pathway. Wnt …

Deubiquitylating enzyme ubiquitin-specific protease 1 (USP1) has been reported to be
aberrantly overexpressed in cancers, and it plays a critical role in regulating various cellular …

Introduction B-cell acute lymphoblastic leukemia (B-ALL) in adults often presents a poor
prognosis. ID1 and ID3 genes have been identified as predictors of poor response in …

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the
clonal expansion of hematopoietic lymphoid progenitors. With new target therapies, the …

Multiple myeloma (MM) is a plasma cell‑associated cancer and accounts for 13% of all
hematological malignancies, worldwide. MM still remains an incurable plasma cell …

Introduction: Although B-cell acute lymphoblastic leukemia (B-cell ALL) survival rates have
improved in recent years, Hispanic children continue to have poorer survival rates. There …

Acute lymphoblastic leukemia (ALL) represents around 25% of adult acute leukemias.
Despite the increasing improvement in the survival rate of ALL patients during the last …