Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Reactive oxygen species (ROS) are chemically active free radicals produced by partial
reduction of oxygen that can activate discrete signaling pathways or disrupt redox …

Site-specific Fe 2+ generation is promising for tumor therapy. Up to now, reported materials
or systems for Fe 2+ delivery do not naturally exist in the body, and their biological safety …

Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death.
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …

Nearly 100 years ago, Otto Warburg undertook a study of tumor metabolism, and discovered
increased lactate caused by increased glycolysis in cancer cells. His experiments were …

Abstract Purpose: Pharmacologic ascorbate (P-AscH−) is hypothesized to be an iron (Fe)-
dependent tumor-specific adjuvant to chemoradiation in treating glioblastoma (GBM). This …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

Cancer is the primary cause of human mortality in most countries. This tendency has
increased as various medical therapeutics have advanced, which suggests that we cannot …

Ferumoxytol (FMX) is an FDA-approved magnetite (Fe 3 O 4) nanoparticle used to treat iron
deficiency anemia that can also be used as an MR imaging agent in patients that can't …

Chemoradiation has remained the standard of care treatment for many of the most
aggressive cancers. However, despite effective toxicity to cancer cells, current …