Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials

J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

Recent progress in bile acid-based antimicrobials

C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …

Design, synthesis, characterization and anticancer activity evaluation of deoxycholic acid-chalcone conjugates

S Patel, N Challagundla, RA Rajput, S Mishra - Bioorganic Chemistry, 2022 - Elsevier
A series of deoxycholic acid-chalcone amides were synthesised and tested against the
human lung cancer cell line, A549 and the cervical cancer cell line, SiHa. Among the …

[HTML][HTML] The role of bile acids in cardiovascular diseases: from mechanisms to clinical implications

S Zhang, J Zhou, W Wu, Y Zhu, X Liu - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Bile acids (BAs), key regulators in the metabolic network, are not only involved in lipid
digestion and absorption but also serve as potential therapeutic targets for metabolic …

Using Nuclear Magnetic Resonance Spectroscopy to Probe Hydrogels Formed by Sodium Deoxycholate

P Li, C Malveau, XX Zhu, JD Wuest - Langmuir, 2021 - ACS Publications
Hydrogels of bile acids and their salts are promising materials for drug delivery, cellular
immobilization, and other applications. However, these hydrogels are poorly understood at …

Bile acid-based receptors and their applications in recognition

S Patel, D Bariya, R Mishra, S Mishra - Steroids, 2022 - Elsevier
Ion recognition has attracted great attention in the past decades because of its important role
in biology, medicine, environment, and chemistry. The combination of rigidity, curved …

Bile acid permeation enhancement for inner ear cochlear drug pharmacological uptake: bio-nanotechnologies in chemotherapy-induced hearing loss

L Carey, D Walker, M Jones, C Ionescu… - Therapeutic …, 2021 - Taylor & Francis
Ototoxicity is the damage to inner ear sensory epithelia due to exposure to certain
medications and chemicals. This occurs when toxins enter the tightly controlled inner ear …

Synthesis of bile acid-thiadiazole conjugates as antibacterial and antioxidant agents

S Patel, S Mishra - Steroids, 2023 - Elsevier
The synthesis, characterization, and antibacterial and antioxidant activity of thiadiazole-
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …

Synthesis and Biological Evaluation of Bile Acid–Triclosan Conjugates: A Study on Antibacterial, Antibiofilm, and Molecular Docking

NV Rathod, S Mishra - Bioconjugate Chemistry, 2025 - ACS Publications
This work describes the synthesis, characterization, and antibacterial properties of four bile
acid–triclosan conjugates. The in vitro antibacterial activity of synthetic bile acid–triclosan …

Self-Assembly of an Amphiphilic Bile Acid Dimer: A Combined Experimental and Theoretical Study of Its Medium-Responsive Fluorescence

GI Santiago-Sampedro, A Aguilar-Granda… - The Journal of …, 2022 - ACS Publications
This work describes the synthesis and aggregation behavior of a dimeric bile acid derivative
in which two steroid cores are bridged by ap-di (phenylethynyl) phenylene fluorophore. The …