The obese adipose tissue microenvironment in cancer development and progression

DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

Extracellular vesicles as signaling mediators and disease biomarkers across biological barriers

P Simeone, G Bologna, P Lanuti… - International journal of …, 2020 - mdpi.com
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific
biological information and have progressively emerged as key regulators of organized …

New insights into extracellular vesicle biogenesis and function

A Latifkar, YH Hur, JC Sanchez… - Journal of cell …, 2019 - journals.biologists.com
It is becoming increasingly evident that most cell types are capable of forming and releasing
multiple distinct classes of membrane-enclosed packages, referred to as extracellular …

Collagen microarchitecture mechanically controls myofibroblast differentiation

BR Seo, X Chen, L Ling, YH Song… - Proceedings of the …, 2020 - National Acad Sciences
Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …

Extracellular vesicles and matrix remodeling enzymes: the emerging roles in extracellular matrix remodeling, progression of diseases and tissue repair

M Nawaz, N Shah, BR Zanetti, M Maugeri, RN Silvestre… - Cells, 2018 - mdpi.com
Extracellular vesicles (EVs) are membrane enclosed micro-and nano-sized vesicles that are
secreted from almost every species, ranging from prokaryotes to eukaryotes, and from …

Extracellular vesicles are integral and functional components of the extracellular matrix

K Rilla, AM Mustonen, UT Arasu, K Härkönen… - Matrix Biology, 2019 - Elsevier
Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …

3D bioprinting of breast cancer models for drug resistance study

Y Wang, W Shi, M Kuss, S Mirza, D Qi… - ACS biomaterials …, 2018 - ACS Publications
Adipose-derived mesenchymal stem/stromal cells (ADMSC) are one of the major stromal
cells in the breast cancer microenvironment that promote cancer progression. Previous …

The key role of extracellular vesicles in the metastatic process

H Zhao, A Achreja, E Iessi, M Logozzi, D Mizzoni… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Extracellular vesicles (EVs), including exosomes, have a key role in the paracrine
communication between organs and compartments. EVs shuttle virtually all types of …

Impact of the different preparation methods to obtain human adipose-derived stromal vascular fraction cells (AD-SVFs) and human adipose-derived mesenchymal …

P Gentile, C Calabrese, B De Angelis… - International journal of …, 2019 - mdpi.com
Autologous therapies using adipose-derived stromal vascular fraction (AD-SVFs) and adult
adipose-derived mesenchymal stem cells (AD-MSCs) warrant careful preparation of the …

Concise review: adipose-derived stem cells (ASCs) and adipocyte-secreted exosomal microRNA (A-SE-miR) modulate cancer growth and promote wound repair

P Gentile, S Garcovich - Journal of clinical medicine, 2019 - mdpi.com
Adipose-derived stem cells (ASCs) have been routinely used from several years in
regenerative surgery without any definitive statement about their potential pro-oncogenic or …