Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …

GSDMB is associated with several inflammatory diseases, such as asthma, sepsis and
colitis. GZMA is released by cytotoxic lymphocytes and cleaves GSDMB at the K244 site and …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but
Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities in several …

Background: Bladder cancer is the fourth and tenth most common malignancy in men and
women worldwide, respectively. One of the main reasons for the unsatisfactory therapeutic …

Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …