Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular
carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) …

Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying
mechanisms are poorly understood. We describe an mTOR-driven mouse model that …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …

Conclusions HBsAg‐positive patients with HCC are at high or intermediate risk of HBV
reactivation depending on the type of HCC therapy. Nucleos (t) ide analogue prophylaxis …