Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key role
in melanocyte differentiation through the direct transcriptional control of TYROSINASE …

Melanocytes differentiate from the neural crest (NC), which is a transient population of cells
that delaminates from the neural tube and migrates extensively throughout the embryo …

Cell cycle exit is required for proper differentiation in most cells and is critical for normal
development, tissue homeostasis, and tumor suppression. However, the mechanisms that …

Human neurocristopathies include a number of syndromes, tumors, and dysmorphologies of
neural crest (NC) stem cell derivatives. In recent years, many white spotting genes have …

Haploid embryonic stem (ES) cells combine haploidy and pluripotency, enabling direct
genetic analyses of recessive phenotypes in vertebrate cells. Haploid cells have been …

The enormous variety of pigmentation phenotypes in nature reflects a series of remarkable
events that begin in the neural crest and end with the manufacture and distribution of …

The first neural crest cells to emigrate from the neural tube are specified as neurons and
glial cells and are subsequently followed by melanocytes of the skin. We wished to …

The common carp is one of the most important freshwater aquaculture fish. The quality is an
emerging concern for aquatic animals, and wild-caught fish is considered to exhibit better …