Primary membranous nephropathy (MN) is a kidney-specific autoimmune glomerular
disease and the leading cause of nephrotic syndrome (NS) in White adults, usually caused …

In glomerulopathies, endothelial dysfunction and the presence of histological vascular
lesions such as thrombotic microangiopathy, arteriolar hyalinosis, and arteriosclerosis are …

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …

Uncontrolled complement activation can cause or contribute to glomerular injury in multiple
kidney diseases. While complement activation plays a causal role in atypical hemolytic …

Primary membranous nephropathy (PMN) is an immune-mediated glomerular disease.
Rituximab (RTX) is recommended as a first-line immunosuppressive therapy and shows …

Introduction: The disruption of podocyte structure and function are the main pathological
mechanism of membranous nephropathy (MN). Phospholipases A2, Group XII B …

Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy. Genetic
variants in complement proteins are found in≈ 60% of patients. Of these patients,≈ 15 …

移植肾血栓性微血管病(TMA) 是肾移植术后的一种致死性并发症, 严重影响肾移植受者和移植肾
的长期生存. 移植肾TMA 可分为新发性TMA 和复发性非典型溶血性尿毒综合征(aHUS) …

Обоснование. Круг заболеваний, характеризующихся развитием почечной
тромботической микроангиопатии (ТМА), включает в себя злокачественную …

Background. The spectrum of diseases characterized by the development of renal
thrombotic microangiopathy (TMA) encompasses the malignant hypertension (MHT). TMA in …